The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2011
Filed:
Jun. 26, 2006
Alexei Bagrov, Bel Air, MD (US);
Olga V. Fedorova, Bel Air, MD (US);
Edward G. Lakatta, Bel Air, MD (US);
Andrey Simbirtsev, St. Petersburg, RU;
Alexander Kotov, St. Petersburg, RU;
Nikolai Kolodkin, St. Petersburg, RU;
Alexei Bagrov, Bel Air, MD (US);
Olga V. Fedorova, Bel Air, MD (US);
Edward G. Lakatta, Bel Air, MD (US);
Andrey Simbirtsev, St. Petersburg, RU;
Alexander Kotov, St. Petersburg, RU;
Nikolai Kolodkin, St. Petersburg, RU;
Abstract
Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also encompasses the use of these monoclonal antibodies or antigen binding fragments in a method for detecting the presence of marinobufagenin in a biological sample. Also provided are methods for the use of these monoclonal antibodies or antigen binding fragments as prophylactic, therapeutic, and diagnostic agents for the detection, inhibition and treatment of a cardiovascular disease, for example, essential hypertension, hypertension associated with preeclampsia, eclampsia, or renal failure, or myocardial fibrosis in a subject.