The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Sep. 08, 2009
Earl J. Bergey, South Dayton, NY (US);
Adela Bonoiu, N. Tonawanda, NY (US);
Supriya Mahajan, Amherst, NY (US);
Paras N. Prasad, Williamsville, NY (US);
Indrajit Roy, Amherst, NY (US);
Stanley A. Schwartz, East Amherst, NY (US);
Ken-tye Yong, Tonawanda, NY (US);
Earl J. Bergey, South Dayton, NY (US);
Adela Bonoiu, N. Tonawanda, NY (US);
Supriya Mahajan, Amherst, NY (US);
Paras N. Prasad, Williamsville, NY (US);
Indrajit Roy, Amherst, NY (US);
Stanley A. Schwartz, East Amherst, NY (US);
Ken-Tye Yong, Tonawanda, NY (US);
The Research Foundation of State University of New York, Amherst, NY (US);
Abstract
Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.