The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Nov. 18, 2009
Shahriar Shane Taremi, Cambridge, MA (US);
Gaolian Xie, Edison, NJ (US);
Thomas Hesson, Cambridge, MA (US);
Jose S. Duca, Cranford, NJ (US);
Corey Strickland, Martinsville, NJ (US);
William T. Windsor, East Brunswick, NJ (US);
Vincent S. Madison, Ukiah, CA (US);
Rumin Zhang, Edison, NJ (US);
Paul Reichert, Montville, NJ (US);
Yaolin Wang, Short Hills, NJ (US);
Shahriar Shane Taremi, Cambridge, MA (US);
Gaolian Xie, Edison, NJ (US);
Thomas Hesson, Cambridge, MA (US);
Jose S. Duca, Cranford, NJ (US);
Corey Strickland, Martinsville, NJ (US);
William T. Windsor, East Brunswick, NJ (US);
Vincent S. Madison, Ukiah, CA (US);
Rumin Zhang, Edison, NJ (US);
Paul Reichert, Montville, NJ (US);
Yaolin Wang, Short Hills, NJ (US);
Schering Corp., Kenilworth, NJ (US);
Abstract
The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention. The invention also provides crystals of modified Hdm2 proteins that are suitable for X-ray crystallization analysis. The present invention also discloses methods of using the modified Hdm2 proteins and crystals thereof to identify, select and/or design compounds that may be used as anticancer agents. The present invention further discloses compounds that bind to modified Hdm2 proteins in protein-ligand complexes.