The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Jun. 24, 2010
Michael D. Bentley, Huntsville, AL (US);
Tacey X. Viegas, Madison, AL (US);
Richard R. Goodin, Fayerville, TN (US);
Lin Cheng, Huntsville, AL (US);
Xuan Zhao, Huntsville, AL (US);
Michael D. Bentley, Huntsville, AL (US);
Tacey X. Viegas, Madison, AL (US);
Richard R. Goodin, Fayerville, TN (US);
Lin Cheng, Huntsville, AL (US);
Xuan Zhao, Huntsville, AL (US);
Nektar Therapeutics, San Francisco, CA (US);
Abstract
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.