The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Aug. 28, 2006
Ralph R. Weichselbaum, Chicago, IL (US);
Donald W. Kufe, Wellesley, MA (US);
Mitchell Posner, Chicago, IL (US);
Helena Mauceri, Wheaton, IL (US);
James O. Park, New York, NY (US);
Ralph R. Weichselbaum, Chicago, IL (US);
Donald W. Kufe, Wellesley, MA (US);
Mitchell Posner, Chicago, IL (US);
Helena Mauceri, Wheaton, IL (US);
James O. Park, New York, NY (US);
The University of Chicago, Chicago, IL (US);
Dana-Farber Cancer Institute, Boston, MA (US);
Abstract
The present invention relates to methods of inducing expression of a polynucleotide encoding a therapeutic polypeptide, e.g., TNF-α, in a cell comprising contacting the cell with a construct comprising an Egr-1 promoter operably linked to a polynucleotide encoding the polypeptide, and at least one chemotherapeutic agent, wherein the chemotherapeutic agent induces expression of the polypeptide. The invention also relates to methods of inhibiting a neoplastic cell, comprising contacting the cell with a construct comprising an Egr-1 promoter operably linked to a polynucleotide encoding TNF-α and a chemotherapeutic agent. The present invention further relates to methods of inhibiting or reducing the growth of a tumor in a subject, comprising co-administering to the subject a construct comprising an Egr-1 promoter operably linked to a polynucleotide encoding TNF-α and a chemotherapeutic agent, wherein the co-administration inhibits or reduces the ability of the tumor to grow.