The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Aug. 02, 2006
Gerardus Jacobus Antonius Maria Strous, Haaften, NL;
Petrus Johannes Maria Van Kerkhof, Beneden Leeuwen, NL;
Gerardus Jacobus Antonius Maria Strous, Haaften, NL;
Petrus Johannes Maria Van Kerkhof, Beneden Leeuwen, NL;
Recharge B.V., Bussum, NL;
Abstract
The invention relates to the field of regulating metabolic processes, for example, to regulate the presence and/or activity of a receptor at the surface of a cell. The invention provides a method for controlling the presence of a receptor at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of the receptor, wherein the ubiquitin/proteasome binding site comprises particular amino acid sequences. The invention further provides a method for controlling the presence of a growth hormone receptor (GHR) at the surface of a cell comprising interfering with the interaction of an F-box protein with a ubiquitin/proteasome binding site of the GHR.