The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 11, 2011
Filed:
Aug. 04, 2000
Martin Handfield, Gainesville, FL (US);
Ann Progulske-fox, Keystone Heights, FL (US);
L. Jeannine Brady, Gainesville, FL (US);
Jeffrey D. Hillman, Gainesville, FL (US);
Martin Handfield, Gainesville, FL (US);
Ann Progulske-Fox, Keystone Heights, FL (US);
L. Jeannine Brady, Gainesville, FL (US);
Jeffrey D. Hillman, Gainesville, FL (US);
Oragenics, Inc., Alachua, FL (US);
Abstract
Disclosed are methods for obtaining antigens that are expressed by pathogenic microorganism during an infection process, as well as the antigens so obtained. Also disclosed are isolated polynucleotides encoding said antigens, recombinant polypeptides expressed from the isolated polypeptides, antibodies capable of forming immune complexes with the obtained antigens, and various other compositions useful in the detection, diagnosis, prevention and/or treatment of a microbial infection. The methods of the invention utilize pooled sera from patients who have partly or completely undergone infection by a microbial organism in order to obtain genes that are expressed during in vivo but not during in vitro growth of the microbial organism.