The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 11, 2011

Filed:

Nov. 21, 2007
Applicants:

Mark E. Meyerhoff, Ann Arbor, MI (US);

Melissa M. Reynolds, Ann Arbor, MI (US);

Megan Frost, Ypsilanti, MI (US);

Sangyeul Hwang, Ann Arbor, MI (US);

Yiduo Wu, Ann Arbor, MI (US);

Inventors:

Mark E. Meyerhoff, Ann Arbor, MI (US);

Melissa M. Reynolds, Ann Arbor, MI (US);

Megan Frost, Ypsilanti, MI (US);

Sangyeul Hwang, Ann Arbor, MI (US);

Yiduo Wu, Ann Arbor, MI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 33/34 (2006.01); A61K 38/44 (2006.01); A61F 2/00 (2006.01); C12N 11/00 (2006.01); C12N 11/02 (2006.01); C12N 11/08 (2006.01); C12N 9/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.


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