The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2011
Filed:
Jan. 30, 2006
Yoshinori Sekiguchi, Tokyo, JP;
Takeshi Kuwada, Tokyo, JP;
Masato Hayashi, Tokyo, JP;
Dai Nozawa, Tokyo, JP;
Yuri Amada, Tokyo, JP;
Tsuyoshi Shibata, Tokyo, JP;
Shuji Yamamoto, Tokyo, JP;
Hiroshi Ohta, Tokyo, JP;
Taketoshi Okubo, Tokyo, JP;
Takeshi Koami, Tokyo, JP;
Yoshinori Sekiguchi, Tokyo, JP;
Takeshi Kuwada, Tokyo, JP;
Masato Hayashi, Tokyo, JP;
Dai Nozawa, Tokyo, JP;
Yuri Amada, Tokyo, JP;
Tsuyoshi Shibata, Tokyo, JP;
Shuji Yamamoto, Tokyo, JP;
Hiroshi Ohta, Tokyo, JP;
Taketoshi Okubo, Tokyo, JP;
Takeshi Koami, Tokyo, JP;
Taisho Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.