Substituted triazines as prion protein ligands and their use to detect or remove prions

Abstract

Compounds of formula (I) wherein Rand Rare the same or different and are each optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl groups; Ris hydrogen or an aryl group substituent or Ris a solid support optionally attached via a spacer; Z represents an oxygen atom, a sulphur atom or NR; Y represents an oxygen atom, a sulphur atom or NR; in which Rand R, which may be the same or different, represent hydrogen, optionally substituted alkyl containing 1 to 6 carbon atoms, optionally substituted phenyl, optionally substituted benzyl or optionally substituted β-phenylethyl; and one of Xand Xrepresents a nitrogen atom and the other of Xand Xrepresents a nitrogen atom or CR, in which Rrepresents hydrogen or an aryl group substituent; are useful for the affinity binding of a prion protein.