The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2011
Filed:
Mar. 11, 2009
David A. Stein, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Sina Bavari, Frederick, MD (US);
Dwight D. Weller, Corvallis, OR (US);
David A. Stein, Corvallis, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Sina Bavari, Frederick, MD (US);
Dwight D. Weller, Corvallis, OR (US);
AVI BioPharma Inc., Corvallis, OR (US);
U.S. Army Medical Research and Material Command, Frederick, MD (US);
Abstract
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the Ebola virus AUG start site region of VP24; ii) the Ebola virus AUG start site region of VP35; iii) the Marburg virus AUG start site region of VP24; or iv) the Marburg virus AUG start site region of NP.