The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2011
Filed:
Aug. 06, 2008
Liying Wang, Jilin province, CN;
Dali HU, Jilin province, CN;
Ran Sun, Jilin province, CN;
Yongli Yu, Jilin province, CN;
Liying Wang, Jilin province, CN;
Dali Hu, Jilin province, CN;
Ran Sun, Jilin province, CN;
Yongli Yu, Jilin province, CN;
Changchun Huapu Biotechnology Co., Ltd., Changchun, Jilin, CN;
Abstract
An oligonucleotide with a nucleotide sequence of 5'-cctcctcctcctcctcctcctcct-3′ (SEQ ID NO: 1) inhibits proliferation of human PBMC activated by TLR9 agonist and interferon production from human PBMC induced by TLR9 agonist, HSV-1, flu virus and serum from SLE patients, and rescues the mice from cytokine-mediated lethal shock. This oligonucleotide can be used as a remedy for the treatment of systemic lupus erythematosus (SLE), sepsis, multiple organ dysfunction syndromes and other immune-mediated disorders.