The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2011
Filed:
Sep. 27, 2005
Thomas Meitinger, Munich, DE;
Tim Matthias Strom, Munich, DE;
Saskia Biskup, Stuttgart, DE;
Marius Ueffing, Munich, DE;
Elisabeth Kremmer, Freising, DE;
Christian Johannes Gloeckner, Rottenburg-Hailfingen, DE;
Thomas Gasser, Tuebingen, DE;
Petra Herzig, Basel, CH;
Friedrich Asmus, Tuebingen, DE;
Nadja Patenge, Rostock, DE;
Alexander Zimprich, Wien, AU;
Matthew J. Farrer, Jacksonville, FL (US);
Jennifer M. Kachergus, Atlantic Beach, FL (US);
Sara J. Lincoln, Jacksonville, FL (US);
Mary M. Hulihan, Atlanta, GA (US);
Zibigniew Wszolek, Jacksonville, FL (US);
Ryan Uitti, Jacksonville, FL (US);
Thomas Meitinger, Munich, DE;
Tim Matthias Strom, Munich, DE;
Saskia Biskup, Stuttgart, DE;
Marius Ueffing, Munich, DE;
Elisabeth Kremmer, Freising, DE;
Christian Johannes Gloeckner, Rottenburg-Hailfingen, DE;
Thomas Gasser, Tuebingen, DE;
Petra Herzig, Basel, CH;
Friedrich Asmus, Tuebingen, DE;
Nadja Patenge, Rostock, DE;
Alexander Zimprich, Wien, AU;
Matthew J. Farrer, Jacksonville, FL (US);
Jennifer M. Kachergus, Atlantic Beach, FL (US);
Sara J. Lincoln, Jacksonville, FL (US);
Mary M. Hulihan, Atlanta, GA (US);
Zibigniew Wszolek, Jacksonville, FL (US);
Ryan Uitti, Jacksonville, FL (US);
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH), Neuherberg, DE;
Eberhard Karls Universitaet Tuebingen, Tuebingen, DE;
Mayo Foundation for Medical Education and Research, Jacksonville, FL (US);
Abstract
The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.