The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2011
Filed:
Apr. 22, 2010
Jens BO Rode Hansen, Hellerup, DK;
Charlotte Albaek Thrue, Copenhagen, DK;
Majken Westergaard, Birkerod, DK;
Kamille Dumong Petersen, Lyngby, DK;
Margit Wissenbach, Fredensborg, DK;
Jens Bo Rode Hansen, Hellerup, DK;
Charlotte Albaek Thrue, Copenhagen, DK;
Majken Westergaard, Birkerod, DK;
Kamille Dumong Petersen, Lyngby, DK;
Margit Wissenbach, Fredensborg, DK;
Santaris Pharma A/S, Horsholm, DK;
Enzon Pharmaceuticals, Inc., Bridgewater, NJ (US);
Abstract
Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.