The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2011
Filed:
Dec. 20, 2005
Suzanne Ostrand-rosenberg, Columbia, MD (US);
Sivasubramanina Baskar, Willcott City, MD (US);
Laurie H. Glimcher, West Newton, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Suzanne Ostrand-Rosenberg, Columbia, MD (US);
Sivasubramanina Baskar, Willcott City, MD (US);
Laurie H. Glimcher, West Newton, MA (US);
Gordon J. Freeman, Brookline, MA (US);
Lee M. Nadler, Newton, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
University of Maryland, Baltimore, MD (US);
Abstract
Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic acid encoding a T cell costimulatory molecule, by using an agent which induces or increases expression of a T cell costimulatory molecule on the tumor cell surface or by coupling a T cell costimulatory molecule to the tumor cell surface. Tumor cells further modified to express MHC class I and/or class II molecules or in which expression of an MHC associated protein, the invariant chain, is inhibited are also disclosed. The modified tumor cells of the invention can be used in methods for treating-a patient with a tumor, preventing or inhibiting metastatic spread of a tumor or preventing or inhibiting recurrence of a tumor. A method for specifically inducing a CD4T cell response against a tumor and a method for treating a tumor by modification of tumor cells in vivo are disclosed.