The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2011
Filed:
Jul. 19, 2007
Toshio Doi, Kyoto, JP;
Hideharu Abe, Tokushima, JP;
Naoshi Fukushima, Shizuoka, JP;
Hitoshi Tai, Shizuoka, JP;
Takakazu Mizuno, Kanagawa, JP;
Masahiko Kinosaki, Shizuoka, JP;
Toshio Doi, Kyoto, JP;
Hideharu Abe, Tokushima, JP;
Naoshi Fukushima, Shizuoka, JP;
Hitoshi Tai, Shizuoka, JP;
Takakazu Mizuno, Kanagawa, JP;
Masahiko Kinosaki, Shizuoka, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
When an anti-human BMP antibody was added to cells of an immortalized human mesangial cell line cultured in the presence of human BMP, the anti-human BMP antibody significantly suppressed the production of type IV collagen in mesangial cells. A number of signaling pathways are involved in abnormal proliferation of type IV collagen. It was therefore completely unpredictable whether merely blocking the BMP signal would indeed suppress the abnormal proliferation of type IV collagen. However, for the first time, the present inventors demonstrated that anti-BMP antibodies are very effective in suppressing the abnormal proliferation of type IV collagen. Thus, anti-BMP antibodies can be used as novel therapeutic agents for kidney diseases associated with abnormal proliferation of the mesangial matrix.