The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 27, 2011
Filed:
Mar. 23, 2007
Pär Gellerfors, Lidingö, SE;
Lars Lannfelt, Stockholm, SE;
Dag Sehlin, Uppsala, SE;
Frida Ekholm Pettersson, Uppsala, SE;
Hillevi Englund, Uppsala, SE;
Pär Gellerfors, Lidingö, SE;
Lars Lannfelt, Stockholm, SE;
Dag Sehlin, Uppsala, SE;
Frida Ekholm Pettersson, Uppsala, SE;
Hillevi Englund, Uppsala, SE;
BioArctic Neuroscience AB, Stockholm, SE;
Abstract
The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(C1q) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.