The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2011
Filed:
Jun. 11, 2008
Jan Grimm, Dübendorf, CH;
Roger Nitsch, Zumikon, CH;
Marlen Knobloch, Zurich, CH;
Uwe Konietzko, Constance, DE;
Markus Rudin, Eglisau, CH;
Thomas Müggler, Basel, CH;
Felicitas Kranz, Zurich, CH;
Jan Grimm, Dübendorf, CH;
Roger Nitsch, Zumikon, CH;
Marlen Knobloch, Zurich, CH;
Uwe Konietzko, Constance, DE;
Markus Rudin, Eglisau, CH;
Thomas Müggler, Basel, CH;
Felicitas Kranz, Zurich, CH;
The University of Zurich, Zurich, CH;
Abstract
Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-β (Aβ) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.