The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2011
Filed:
Jun. 13, 2008
Lok Wai Lawrence Woo, Slough, GB;
Toby Jackson, Slough, GB;
Atul Purohit, Slough, GB;
Michael John Reed, Slough, GB;
Barry Victor Lloyd Potter, Slough, GB;
Lok Wai Lawrence Woo, Slough, GB;
Toby Jackson, Slough, GB;
Atul Purohit, Slough, GB;
Michael John Reed, Slough, GB;
Barry Victor Lloyd Potter, Slough, GB;
Sterix Limited, Slough, Berkshire, GB;
Abstract
There is provided a compound of Formula I wherein R, R, R, Rand Rare independently selected from H and —Y—R; wherein each Ris independently selected from —OH, hydrocarbyl groups, oxyhydrocarbyl groups, cyano (—CN), nitro (—NO), H-bond acceptors, and halogens; wherein at least one of R, R, R, Rand Ris —Y—Rwherein Ris selected from substituted and unsubstituted heterocyclic rings and amino substituted phenyl groups, wherein X is a bond or a linker group; wherein Y is an optional linker group; and wherein ring A is optionally further substituted; wherein Ris selected from H, —OH and —OSONRR; wherein Rand Rare independently selected from H and hydrocarbyl; wherein (a) X is a bond and at least one of R, R, R, Rand Ris —Y—R; OR (b) Ris —OSONRRor —OH and four of R, R, R, Rand Rare H and one of R, R, R, Rand Ris —Y—R. These compounds inhibit steroid sulphatase and aromatase activity and are useful in the treatment of endocrine-dependent tumors.