The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 20, 2011
Filed:
Aug. 25, 2004
Naoto T. Ueno, Houston, TX (US);
Hideki Ishihara, Hyogo, JP;
Tamotsu Sudo, Kobe, JP;
Tomoko Matsushima, Kobe, JP;
Naoto T. Ueno, Houston, TX (US);
Hideki Ishihara, Hyogo, JP;
Tamotsu Sudo, Kobe, JP;
Tomoko Matsushima, Kobe, JP;
Board of Regents, The University of Texas System, Austin, TX (US);
Sysmex Corporation, Kobe, JP;
Abstract
The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cycle molecules in a cancer cell. Such a method makes use of an automated analyzer system wherein cell cycle parameters (molecules) such as CDK1 kinase activity, CDK1 expression, CDK2 kinase activity, CDK2 expression, MAD2 expression, Cyclin B1, Cyclin E expression, p21 expression, and CDK6 expression; are assessed. The present invention further provides a method of obtaining a cell cycle profile of a cancer cell that is sensitive to a taxane.