The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Feb. 27, 2007
Applicants:
Mark Searcey, London, GB;
Laurence Hylton Patterson, London, GB;
Inventors:
Mark Searcey, London, GB;
Laurence Hylton Patterson, London, GB;
Assignee:
University of Bradford, Bradford, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4035 (2006.01); A61K 31/4185 (2006.01); A61K 31/4188 (2006.01);
U.S. Cl.
CPC ...
Abstract
Compounds of the general formula (I) or (IA) in which X is H, Y is a leaving group, Rpreferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which C is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumors. The prodrug is expected to be activated preferentially in tumor cells, which it will act as a DNA alkylating agent preventing cell division.