The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 13, 2011
Filed:
Feb. 02, 2006
Kevin J. Lee, New York, NY (US);
Richard Axel, NY, NY (US);
Walter Strapps, NY, NY (US);
Gilad Barnea, NY, NY (US);
Kevin J. Lee, New York, NY (US);
Richard Axel, NY, NY (US);
Walter Strapps, NY, NY (US);
Gilad Barnea, NY, NY (US);
Life Technologies Corporation, Carlsbad, CA (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.