The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Dec. 07, 2007
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Michael James Rishel, Rensselaer, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
Kande Kankanamalage Dayarathna Amarasinghe, Latham, NY (US);
Michael James Rishel, Rensselaer, NY (US);
Sean Richard Dinn, Delmar, NY (US);
Bruce Fletcher Johnson, Scotia, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
The present invention provides novel fluoroalkyl tetrabenazine carbinol compounds having structure I wherein Ris a C-Cfluorinated aliphatic radical; Ris a C-Caliphatic radical; Ris hydrogen or a C-Caliphatic radical; Ris hydrogen or a C-Caliphatic radical; and Ris hydrogen, a C-Caliphatic radical, a C-Ccycloaliphatic radical, or a C-Caromatic radical. In a particular embodiment, —ORis an ester moiety. The fluoroalkyl tetrabenazine carbinol compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The fluoroalkyl tetrabenazine carbinol compounds are shown to possess high affinity for VMAT-2, a biomarker implicated in human diabetes. The fluoroalkyl tetrabenazine carbinol compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabled fluoroalkyl tetrabenazine carbinol compounds are useful as probes for the discovery of PET imaging agents.