The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
May. 15, 2006
Michel Belley, Pierre Fonds, CA;
Jason Burch, Westmount, CA;
John Colucci, Kirkland, CA;
Julie Farand, Montreal, CA;
Mario Girard, Saint-Lazare, CA;
Yongxin Han, Kirkland, CA;
Michel Belley, Pierre Fonds, CA;
Jason Burch, Westmount, CA;
John Colucci, Kirkland, CA;
Julie Farand, Montreal, CA;
Mario Girard, Saint-Lazare, CA;
Yongxin Han, Kirkland, CA;
Merck Canada Inc., Quebec, CA;
Abstract
The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.