The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Mar. 19, 2004
Lynne Canne Bannen, Pacifica, CA (US);
S. David Brown, San Carlos, CA (US);
Wei Cheng, South San Francisco, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
John M. Nuss, Danville, CA (US);
Morrison B. Mac, San Francisco, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Matthew A. Williams, San Mateo, CA (US);
Wei Xu, Danville, CA (US);
Atwood Kim Cheung, Cambridge, MA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Sergey Epshteyn, Fremont, CA (US);
Mohamed Abdulkader Ibrahim, Mountain View, CA (US);
James William Leahy, San Leandro, CA (US);
Gary Lee Lewis, San Francisco, CA (US);
Robin Tammie Noguchi, San Bruno, CA (US);
Larry Wayne Mann, Richland, MI (US);
Brian Hugh Ridgway, Belmont, CA (US);
Joan C. Sangalang, Mountain View, CA (US);
Kevin Luke Schnepp, Elk Grove, CA (US);
Xian Shi, San Bruno, CA (US);
Richard George Khoury, Redwood City, CA (US);
Lynne Canne Bannen, Pacifica, CA (US);
S. David Brown, San Carlos, CA (US);
Wei Cheng, South San Francisco, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
John M. Nuss, Danville, CA (US);
Morrison B. Mac, San Francisco, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Matthew A. Williams, San Mateo, CA (US);
Wei Xu, Danville, CA (US);
Atwood Kim Cheung, Cambridge, MA (US);
Lisa Esther Dalrymple, San Francisco, CA (US);
Sergey Epshteyn, Fremont, CA (US);
Mohamed Abdulkader Ibrahim, Mountain View, CA (US);
James William Leahy, San Leandro, CA (US);
Gary Lee Lewis, San Francisco, CA (US);
Robin Tammie Noguchi, San Bruno, CA (US);
Larry Wayne Mann, Richland, MI (US);
Brian Hugh Ridgway, Belmont, CA (US);
Joan C. Sangalang, Mountain View, CA (US);
Kevin Luke Schnepp, Elk Grove, CA (US);
Xian Shi, San Bruno, CA (US);
Richard George Khoury, Redwood City, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.