The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Sep. 28, 2000
Stephen Arkinstall, Belmont, MA (US);
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commungny, FR;
Montserrat Camps, Versoix, FR;
Thomas Rueckle, Plan-les-Ouates, CH;
Jean Pierre Gotteland, Beaumont, FR;
Marco Biamonte, San Diego, CA (US);
Stephen Arkinstall, Belmont, MA (US);
Serge Halazy, Vetraz-Monthoux, FR;
Dennis Church, Commungny, FR;
Montserrat Camps, Versoix, FR;
Thomas Rueckle, Plan-les-Ouates, CH;
Jean Pierre Gotteland, Beaumont, FR;
Marco Biamonte, San Diego, CA (US);
Merck Serono SA, Coinsins, Vaud, CH;
Abstract
The present invention is related to sulfonamide derivatives of formula (I0 notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK 2 and 3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. The compounds of formula (I) according to the present invention being suitable pharmaceutical agents are those wherein Arand Arare independently from each other substituted or unsubstituted aryl or heteroaryl groups, X is O or S, preferably O; Ris hydrogen or a C-C-alkyl group, or Rforms a substituted or unsubstituted 5-6 membered saturated or unsaturated ring with Ar; n is an integer from 0 to 5, preferably between 1-3 and most preferred 1; Y within formula (I) is an unsubstituted or a substituted 4-12-membered saturated cyclic or bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atom, whereby one nitrogen atom within said ring is forming a bond with the sulfonyl group of formula (I) thus providing a sulfonamide.