The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Feb. 10, 2010
Jennifer R. Allen, Newbury Park, CA (US);
Kaustav Biswas, Calabasas, CA (US);
Roland Burli, Pasadena, CA (US);
Jennifer Dao, Oak Park, CA (US);
Michael J. Frohn, Thousand Oaks, CA (US);
Jennifer E. Golden, Simi Valley, CA (US);
Randall W. Hungate, Camarillo, CA (US);
Robert Kurzeja, Newbury Park, CA (US);
Stephanie J. Mercede, Woodland Hills, CA (US);
Kristine M. Muller, Thousand Oaks, CA (US);
Susana C. Neira, Thousand Oaks, CA (US);
Tanya A. N. Peterkin, Woodland Hills, CA (US);
Christopher M. Tegley, Thousand Oaks, CA (US);
Violeta Yu, Moorpark, CA (US);
Jennifer R. Allen, Newbury Park, CA (US);
Kaustav Biswas, Calabasas, CA (US);
Roland Burli, Pasadena, CA (US);
Jennifer Dao, Oak Park, CA (US);
Michael J. Frohn, Thousand Oaks, CA (US);
Jennifer E. Golden, Simi Valley, CA (US);
Randall W. Hungate, Camarillo, CA (US);
Robert Kurzeja, Newbury Park, CA (US);
Stephanie J. Mercede, Woodland Hills, CA (US);
Kristine M. Muller, Thousand Oaks, CA (US);
Susana C. Neira, Thousand Oaks, CA (US);
Tanya A. N. Peterkin, Woodland Hills, CA (US);
Christopher M. Tegley, Thousand Oaks, CA (US);
Violeta Yu, Moorpark, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.