The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Jun. 01, 2009
Applicants:
Margret Oethinger, Bad Oeynhausen, DE;
Stuart B. Levy, Boston, MA (US);
Inventors:
Margret Oethinger, Bad Oeynhausen, DE;
Stuart B. Levy, Boston, MA (US);
Assignee:
Trustees of Tufts College, Medford, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.