The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 06, 2011
Filed:
Jul. 06, 2010
Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
Applicants:
Kohei Miyazono, Shiki, JP;
Takeshe Imamura, Tokyo, JP;
Peter Ten Dijke, Em Hoofddorp, NL;
Inventors:
Assignee:
Ludwig Institute for Cancer Research, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12P 21/00 (2006.01); C07K 14/495 (2006.01); C07K 14/71 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF-β family. The molecule has a role in the phosphorylation of Smad-5 and Smad1, which also act as activators of certain genes. Aspects of the invention relate to this interaction.