Compounds that act as a vehicle for delivery through the blood-brain barrier and charge delivery vehicle constructions

Abstract

Compounds of formula (I), where Rand Rare H or (C-C)-alkyl; Ris H or a C-radical derived from one of the known ring systems with 1-4 rings; Xis a (C-C)-alkyl biradical derived from a linear or branched carbon chain; and Xis —NH—, —NH—(CH)—COO—, —NH—(CH)—S—, or —NH—CO—(CH)—S—, are useful as blood-brain barrier shuttles (BBB). BBB shuttle-cargo constructs, the cargo being a substance susceptible to form an amide or an ester or a disulfide bound with Xand being unable to cross the blood-brain barrier by itself, are useful as medicaments.