The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Nov. 15, 2007
Dan V. Mourich, Albany, OR (US);
Hong M. Moulton, Corvallis, OR (US);
David J. Hinrichs, Lake Oswego, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
Dan V. Mourich, Albany, OR (US);
Hong M. Moulton, Corvallis, OR (US);
David J. Hinrichs, Lake Oswego, OR (US);
Patrick L. Iversen, Corvallis, OR (US);
AVI BioPharma Inc., Corvallis, OR (US);
Abstract
A method and conjugate for selectively killing antigen-activated T cells are disclosed. The conjugate is composed of a substantially uncharged antisense compound targeted against the human cFLIP protein, and a reverse TAT (rTAT) polypeptide coupled covalently to the antisense compound. The rTAT polypeptide is effective to produce selective uptake of the conjugate into antigen-activated T cells, relative to the uptake of the conjugate into non-activated T cells. The cFLIP antisense compound causes activation induced cell death (AICD) of activated lymphocytes. The method is useful in treating transplantation rejection and autoimmune conditions.