The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Nov. 30, 2006
Nikhil V. Dhurandhar, Baton Rouge, LA (US);
Thomas C. Holland, Ann Arbor, MI (US);
Zhong Q. Wang, Baton Rouge, LA (US);
Nikhil V. Dhurandhar, Baton Rouge, LA (US);
Thomas C. Holland, Ann Arbor, MI (US);
Zhong Q. Wang, Baton Rouge, LA (US);
Wayne State Univeristy, Detroit, MI (US);
Board of Sup. of LSU and Agr. & Mechanical College, Baton Rouge, LA (US);
Abstract
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.