The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Aug. 28, 2009
Tianling Chen, Florham Park, NJ (US);
Diane Greeley, Watchung, NJ (US);
John David Rothermel, Sunset Beach, NC (US);
Markus Wartmann, Riehen, CH;
Jeanette Marjorie Wood, Biel-Benken, CH;
TianLing Chen, Florham Park, NJ (US);
Diane Greeley, Watchung, NJ (US);
John David Rothermel, Sunset Beach, NC (US);
Markus Wartmann, Riehen, CH;
Jeanette Marjorie Wood, Biel-Benken, CH;
Novartis AG, Basel, CH;
Abstract
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NR, wherein Ris hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.