The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Jun. 10, 2004
Ekambar R. Kandimalla, Southboro, MA (US);
Lakshmi Bhagat, Brookline, MA (US);
Rajendra K. Pandey, Framingham, MA (US);
Dong Yu, Westboro, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Ekambar R. Kandimalla, Southboro, MA (US);
Lakshmi Bhagat, Brookline, MA (US);
Rajendra K. Pandey, Framingham, MA (US);
Dong Yu, Westboro, MA (US);
Sudhir Agrawal, Shrewsbury, MA (US);
Idera Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention provides immunostimulatory oligonucleotides having at least one CpG dinucleotide and a secondary structure at the 5'- or 3′-end. These oligonucleotides have either reduced or improved immunostimulatory properties. The invention establishes that 5′-terminal secondary structures affect immunostimulatory activity significantly more than those at the 3′-end. The invention also provides methods for increasing or decreasing the immunostimulatory activity of a CpG-containing nucleic acid.