The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Sep. 02, 2010
Hiroyuki Tsunoda, Ibaraki, JP;
Kiyotaka Nakano, Ibaraki, JP;
Tetsuro Orita, Ibaraki, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Yuichi Hirata, Ibaraki, JP;
Hiroyuki Tsunoda, Ibaraki, JP;
Kiyotaka Nakano, Ibaraki, JP;
Tetsuro Orita, Ibaraki, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Yuichi Hirata, Ibaraki, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.