The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2011
Filed:
Jul. 19, 2005
Kazuhiro Machida, Shizuoka, JP;
Akira Arisawa, Shizuoka, JP;
Susumu Takeda, Kumamoto, JP;
Masashi Yoshida, Shizuoka, JP;
Toshio Tsuchida, Shizuoka, JP;
Kazuhiro Machida, Shizuoka, JP;
Akira Arisawa, Shizuoka, JP;
Susumu Takeda, Kumamoto, JP;
Masashi Yoshida, Shizuoka, JP;
Toshio Tsuchida, Shizuoka, JP;
EISAI R&D Management Co., Ltd., Tokyo, JP;
Abstract
The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants that maintain all or a portion of this DNA or variant thereof, and a method of producing the pladienolide macrolide compounds using these transformants. More particularly, it provides an isolated pure DNA that contains at least one region encoding a polypeptide that participates in pladienolide biosynthesis; polypeptide encoded by this DNA; a self-replicating or integrated-replicating recombinant plasmid carrying this DNA; a transformant maintaining this DNA; and a method of producing a pladienolide, characterized by culturing this transformant on culture medium and collecting pladienolide from this culture medium.