The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Oct. 31, 2007
Bart DE Corte, Southampton, PA (US);
Marc René DE Jonge, Hontenissestraat, NL;
Jan Heeres, Vosselaar, BE;
Chih Yung Ho, Lansdale, PA (US);
Paul Adriaan Jan Janssen, Vosselaar, BE;
Frank Xavier Jozef Herwig Arts, Legal Representative, Brasschaat, BE;
Robert W. Kavash, Glenside, PA (US);
Lucien Maria Henricus Koymans, Retie, BE;
Michael Joseph Kukla, Maple Glen, PA (US);
Donald William Ludovici, Quakertown, PA (US);
Koen Jeanne Alfons Van Aken, Kuurne, BE;
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Bart De Corte, Southampton, PA (US);
Marc René de Jonge, Hontenissestraat, NL;
Jan Heeres, Vosselaar, BE;
Chih Yung Ho, Lansdale, PA (US);
Paul Adriaan Jan Janssen, Vosselaar, BE;
Frank Xavier Jozef Herwig Arts, legal representative, Brasschaat, BE;
Robert W. Kavash, Glenside, PA (US);
Lucien Maria Henricus Koymans, Retie, BE;
Michael Joseph Kukla, Maple Glen, PA (US);
Donald William Ludovici, Quakertown, PA (US);
Koen Jeanne Alfons Van Aken, Kuurne, BE;
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Janssen Pharmaceutica, N.V., , BE;
Abstract
This invention concerns the use of compounds of formula the N-oxides, pharmaceutically acceptable addition salts, quaternary amines, stereochemically isomeric forms thereof, wherein -a=a-a=a- forms phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl with the attached vinyl group; n is 0 to 5; Ris hydrogen, aryl, formyl, Calkylcarbonyl, Calkyl, Calkyloxycarbonyl, substituted Calkyl, substituted CalkyloxyCalkylcarbonyl; Ris hydroxy, halo, optionally substituted Calkyl, Calkenyl or Calkynyl, Ccycloalkyl, Calkyloxy, Calkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(Calkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)R, —NH—S(═O)R, —C(═O)R, —NHC(═O)H, —C(═O)NHNH, —NHC(═O)R, —C(═NH)R, 5-membered heterocyclic ring; L is optionally substituted Calkyl, Calkenyl, Calkynyl or Ccycloalkyl; or —X—R; Q is hydrogen, Calkyl, halo, polyhalo-Calkyl, optionally substituted amino group; Y represents hydroxy, halo, Ccycloalkyl, optionally substituted Calkyl, Calkenyl or Calkynyl, Calkyloxy, Calkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono-or di(Calkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, —S(═O)R, —NH—S(═O)R, —C(═O)R, —NHC(═O)H, —C(═O)NHNH, 13 NHC(═O)R,—C(═NH)R, aryl; for the treatment of subjects suffering from HIV infection.