The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Mar. 05, 2010
Bpc-1: a secreted brain-specific protein expressed and secreted by prostate and bladder cancer cells
Daniel E. Afar, Fremont, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Kahan Leong, Playa Del Rey, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas C. Saffran, Encinitas, CA (US);
Aya Jakobovits, Beverly Hills, CA (US);
Daniel E. Afar, Fremont, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Kahan Leong, Playa Del Rey, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas C. Saffran, Encinitas, CA (US);
Aya Jakobovits, Beverly Hills, CA (US);
Agensys, Inc., Santa Monica, CA (US);
Abstract
Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.