The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Oct. 29, 2007
David Festus Charles Moffat, Oxfordshire, GB;
Stephen John Davies, Abingdon, GB;
Michael Hugh Charlton, Abingdon, GB;
Simon Christopher Hirst, Abingdon, GB;
Stuart Thomas Onions, Nottingham, GB;
Jonathan Gareth Williams, Nottingham, GB;
David Festus Charles Moffat, Oxfordshire, GB;
Stephen John Davies, Abingdon, GB;
Michael Hugh Charlton, Abingdon, GB;
Simon Christopher Hirst, Abingdon, GB;
Stuart Thomas Onions, Nottingham, GB;
Jonathan Gareth Williams, Nottingham, GB;
Chroma Therapeutics Ltd., , GB;
Abstract
Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein Ris hydrogen or optionally substituted (C-C)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is (a) a radical of formula RRCHNH—Y-L-X—(CH)— wherein: z is 0 or 1; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; Y is a bond, —C(═O)—, —S(═P)2-, —C(═O)O—, —C(═O)NR3-, —C(═S)—NR, —C(═NH)—NRor —S(═O)NR— wherein Ris hydrogen or optionally substituted C-Calkyl; L is a divalent linker radical of formula -(Alk)(Q)(Alk)- wherein m, n, p, Q, AIkand AIkare as defined in the claims.