The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Feb. 06, 2004
Chris Shaw, Comber, GB;
David Hirst, Belfast, GB;
Tianbao Chen, Belfast, GB;
Martin O'rourke, Carrickfergus, GB;
Pingfan Rao, Fuzhou, CN;
Chris Shaw, Comber, GB;
David Hirst, Belfast, GB;
Tianbao Chen, Belfast, GB;
Martin O'Rourke, Carrickfergus, GB;
Pingfan Rao, Fuzhou, CN;
Queen's University of Belfast, Belfast, GB;
Abstract
A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad () defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH. Also disclosed are kinestatin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including kinestatin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding kinestatin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides. Kinestatin and analogs thereof (including the prodrugs and multimeric and/or fusion peptides) can be used to treat and/or prevent disorders associated with bradykinin, including cardiovascular disorders, inflammation, asthma, allergic rhinitis, pain, angiogenesis and the like.