The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 23, 2011

Filed:

Mar. 30, 2007
Applicants:

Toshikazu Nakamura, Suita, JP;

Kunio Matsumoto, Ibaraki, JP;

Kazuhiro Fukuta, Minoh, JP;

Kiichi Adachi, Toyonaka, JP;

Daichika Hayata, Toyonaka, JP;

Inventors:

Toshikazu Nakamura, Suita, JP;

Kunio Matsumoto, Ibaraki, JP;

Kazuhiro Fukuta, Minoh, JP;

Kiichi Adachi, Toyonaka, JP;

Daichika Hayata, Toyonaka, JP;

Assignees:

Kringle Pharma Inc., Osaka, JP;

Osaka University, Osaka, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); C12P 21/06 (2006.01); C12P 21/04 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); C07K 14/475 (2006.01);
U.S. Cl.
CPC ...
Abstract

An HGF precursor protein variant, in which a peptide structure comprises a sequence including a peptide chain X inserted between an α chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the C-terminus of the α chain are deleted, and a β chain of HGF or a polypeptide where 1 to 20 amino-acid residues from the N-terminus of the β chain are deleted; wherein (i) the peptide chain X has an amino-acid sequence of at least two residues, (ii) the peptide chain X can be cleaved by a protease reaction or a chemical reaction, and (iii) a protein obtained by cleaving at least one site of the peptide chain X has HGF action.


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