The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Dec. 03, 2008
Uwe Kobold, Weilheim, DE;
Thomas Duelffer, Weilheim, DE;
Michael Grol, Feldafing, DE;
Rupert Herrmann, Weilheim, DE;
Herbert Von Der Eltz, Weilheim, DE;
Leopold Von Proff, Hohenpeissenberg, DE;
Uwe Kobold, Weilheim, DE;
Thomas Duelffer, Weilheim, DE;
Michael Grol, Feldafing, DE;
Rupert Herrmann, Weilheim, DE;
Herbert Von der Eltz, Weilheim, DE;
Leopold Von Proff, Hohenpeissenberg, DE;
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Abstract
The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.