The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2011
Filed:
Nov. 04, 2008
J. Glenn Morris, Baltimore, MD (US);
Alexander Sulakvelidze, Towson, MD (US);
Zemphira Alavidze, Tbilisi, GE;
Gary R. Pasternack, Baltimore, MD (US);
Torrey C. Brown, Severna Park, MD (US);
J. Glenn Morris, Baltimore, MD (US);
Alexander Sulakvelidze, Towson, MD (US);
Zemphira Alavidze, Tbilisi, GE;
Gary R. Pasternack, Baltimore, MD (US);
Torrey C. Brown, Severna Park, MD (US);
Intralytix, Inc., Baltimore, MD (US);
Abstract
The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage.