Anthranilic acid derivative or salt thereof

Abstract

An anthranilic acid derivative represented by the general formula (X) [wherein Rrepresents hydrogen or a carboxy-protecting group; Rrepresents optionally substituted phenyl, a heterocyclic group, etc.; Rrepresents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; Xrepresents carbonyl, etc.; Xrepresents optionally substituted alkylene group, a bond, etc.; Xrepresents oxygen, a bond, etc.; and Xrepresents a group represented by the general formula —X—X— or —X—X— (wherein Xmeans oxygen, a bond, etc.; and Xmeans optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-13 production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.