The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2011
Filed:
Jun. 16, 2010
Marc G. Caron, Hillsborough, NC (US);
Martin Beaulieu, Durham, NC (US);
Raul R. Gainetdinov, Chapel Hill, NC (US);
Tatiana D. Sotnikova, Chapel Hill, NC (US);
Sébastien Marion, Durham, NC (US);
Marc G. Caron, Hillsborough, NC (US);
Martin Beaulieu, Durham, NC (US);
Raul R. Gainetdinov, Chapel Hill, NC (US);
Tatiana D. Sotnikova, Chapel Hill, NC (US);
Sébastien Marion, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.