The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2011
Filed:
Nov. 25, 2009
Takanobu Kuroita, Osaka, JP;
Hiroki Sakamoto, Osaka, JP;
Hideyuki Igawa, Osaka, JP;
Minoru Sasaki, Osaka, JP;
Kouhei Asano, Osaka, JP;
Tsuyoshi Maekawa, Osaka, JP;
Koji Fuji, Osaka, JP;
Takanobu Kuroita, Osaka, JP;
Hiroki Sakamoto, Osaka, JP;
Hideyuki Igawa, Osaka, JP;
Minoru Sasaki, Osaka, JP;
Kouhei Asano, Osaka, JP;
Tsuyoshi Maekawa, Osaka, JP;
Koji Fuji, Osaka, JP;
Takeda Pharmaceutical Company Limited, Osaka, JP;
Abstract
A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8', or a salt thereof. For example, the compound may be substituted pyrimidines and pharmaceutical compositions of the formula (I) where X=—CR3; X1=—CR2 or —NR2; and X2=—CR5 or —NR5. The compound of the present invention is useful as a drug for the prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases.