The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2011
Filed:
Apr. 26, 2005
Seong Eon Ryu, Taejeon-si, KR;
Dae Gwin Jeong, Taejeon-si, KR;
Seung-jun Kim, Taejeon-si, KR;
Jae Hoon Kim, Jeju-si, KR;
Jeong Hee Son, Taejeon-si, KR;
Seong Eon Ryu, Taejeon-si, KR;
Dae Gwin Jeong, Taejeon-si, KR;
Seung-Jun Kim, Taejeon-si, KR;
Jae Hoon Kim, Jeju-si, KR;
Jeong Hee Son, Taejeon-si, KR;
Korea Research Institute of Bioscience and Biotechnology, Taejeon-Si, KR;
Abstract
The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and monomers form a trimer through farnesylation site in the C-terminus of said protein. Thus intra-cellular migration and membrane localization can be achieved. The said crystal structure of PRL-1 protein of the present invention is very useful for the development the agent which inhibits carcinogenesis and metastasis of the cancer.