The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Jul. 21, 2006
Masahiro Okuyama, Osaka, JP;
Fumiaki Uehara, Osaka, JP;
Hiroshi Iwamura, Osaka, JP;
Kazutoshi Watanabe, Osaka, JP;
Masahiro Okuyama, Osaka, JP;
Fumiaki Uehara, Osaka, JP;
Hiroshi Iwamura, Osaka, JP;
Kazutoshi Watanabe, Osaka, JP;
Mitsubishi Tanabe Pharma Corporation, Osaka, JP;
Sanofi-Aventis, Paris, FR;
Abstract
Production method of an optically active morpholine compound represented by the formula 10, or a compound represented by the formula 55, which includes the following steps: wherein each symbol is as defined in the specification. An optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4']bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method.