The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Aug. 03, 2006
Antonio Giordani, Pavia, IT;
Stefano Mandelli, Casatenovo, IT;
Ilario Verpilio, Arluno, IT;
Simona Zanzola, Milan, IT;
Francesca Tarchino, Varazze, IT;
Gianfranco Caselli, Milan, IT;
Tiziana Piepoli, Milan, IT;
Silvio Mazzari, Padua, IT;
Francesco Makovec, Lesmo, IT;
Lucio Claudio Rovati, Monza, IT;
Antonio Giordani, Pavia, IT;
Stefano Mandelli, Casatenovo, IT;
Ilario Verpilio, Arluno, IT;
Simona Zanzola, Milan, IT;
Francesca Tarchino, Varazze, IT;
Gianfranco Caselli, Milan, IT;
Tiziana Piepoli, Milan, IT;
Silvio Mazzari, Padua, IT;
Francesco Makovec, Lesmo, IT;
Lucio Claudio Rovati, Monza, IT;
Rottapharm S.p.A., Milan, IT;
Abstract
The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases. Formula I: