IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7994172 B1

PDFFull Text
Date of Patent:
Aug. 09, 2011

Filed:

Dec. 27, 2005

[1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases

Applicants:

Ken Rice, San Rafael, CA (US);

Erick Wang CO, San Diego, CA (US);

Moon Hwan Kim, Palo Alto, CA (US);

Lynn Canne Bannen, Pacifica, CA (US);

Joerg Bussenius, Foster City, CA (US);

Donna Tra Le, San Jose, CA (US);

Amy Lew Tsuhako, Milpitas, CA (US);

John Nuss, Danville, CA (US);

Yong Wang, Foster City, CA (US);

Wei Xu, Danville, CA (US);

Rhett Ronald Klein, Chicago, IL (US);

Inventors:

Ken Rice, San Rafael, CA (US);

Erick Wang Co, San Diego, CA (US);

Moon Hwan Kim, Palo Alto, CA (US);

Lynn Canne Bannen, Pacifica, CA (US);

Joerg Bussenius, Foster City, CA (US);

Donna Tra Le, San Jose, CA (US);

Amy Lew Tsuhako, Milpitas, CA (US);

John Nuss, Danville, CA (US);

Yong Wang, Foster City, CA (US);

Wei Xu, Danville, CA (US);

Rhett Ronald Klein, Chicago, IL (US);

Assignee:

Exelixis, Inc., South San Francisco, CA (US);

Attorney:

McDonnell Boehnen Hulbert & Berhoff LLP

Primary Examiner:

Susanna Moore

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides compounds of formula (I) and methods for inhibition of kinases, more specifically p70S6 kinases, and more preferably p70S6, Akt-1 and Akt-2 kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration, chemoinvasion and metabolism. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Find Patent Forward Citations

Loading…